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Order acetazolamide. The efficacy and safety of a single dose acetazolamide as an antidote for influenza was first documented in 1959 (20); however, the effectiveness and safety of a single acetazolamide dose have not been evaluated in the acute phase of a severe influenza pandemic, which is associated with the greatest morbidity, mortality, and economic impact (2). Because of the high efficacy ketamine against influenza viruses during the acute phase of influenza, there is a real opportunity for the development and clinical evaluation of a single-antigen, intranasal, rapid-onset-antibody (RIBA, abbreviated to RIBA) treatment approach antiviral of the acute phase a severe influenza virus infection. However, the initial studies with ketamine as an RBA agent were conducted in the 1960s, with limited effect (2). Since then, evidence supporting efficacy of the drug has been demonstrated using multiple RBA formulations. In particular, it was reported the early 1990s that an intranasal formulation of ketamine (50 mg/kg) significantly reduced the number of respiratory symptoms and laboratory abnormalities (21). This study also showed significant reductions in severity of respiratory symptoms and laboratory abnormalities in subjects treated with ketamine. Further clinical studies have now shown that intranasal ketamine can be used for the management of influenza (21, 22). In the next section, we describe current clinical literature and present data from a number of clinical trials that have shown the effectiveness of intranasal ketamine when used to help control acute respiratory infections of all severity in adults and children. We describe the efficacy and safety of this intranasal treatment approach with the objective of enabling use drug as a treatment option during the acute phase of a severe influenza pandemic. PATIENTS AND METHODS This is a retrospective observational study of the adverse events reported by patients enrolled in the intranasal ketamine trial and from patients who participated in the study's 2 postmarketing studies. drugstore makeup coupons canada A total of 5,814 adult and 2,974 child patients were enrolled in the intranasal ketamine trial. One hundred and twenty-eight patients were excluded from the study (n = 0) because of excessive drug ingestion, medical illness such as fever or bronchial asthma, other reasons. In addition, 2,095 children (2 adults, 19 children), who did not have an allergic or idiosyncratic response to the ketamine and did not have a contraindication to RBA therapy, were screened in the intranasal ketamine trial. number of patients (all ages) in each of the 2 studies was as follows: 1,047 children, with a mean age of 8.2 years (standard deviation [SD], 0.8 years), were eligible for participation in the 2 Small round white generic xanax postmarketing clinical trials ()
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