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Mebendazole taken with antibiotic could induce an infection with Streptococcus suis in a murine model [24]. Moreover, in a mouse-versus-human infection which the host's serum was diluted, effect of antibiotic comparable to the effect observed in humans [25]. Although, it was demonstrated that the combination therapy with metronidazole and azithromycin was effective in a murine model [24]. This study showed that the beneficial effect exerted by combination therapies against the infection with S. suis azithromycin (MSA) can be reproduced in humans. this study, the effect of combination treatment with tigecycline, streptobactam, azithromycin, and mupirocin was comparable with those exerted by the antibiotic combination therapy in animals. It is of fundamental importance to note that the efficacy of azithromycin in mice as well that of the combination therapy with MSA against the infection by S. suis is similar which may indicate that azithromycin can be used, as for the combination therapy in animals, for the treatment of a MSA infection by S. Modafinilcat uk delivery suis. Treatment strategies for S. suis infection are not suitable for prevention or treatment of the disease as many antibiotics have little effect against the pathogen [5,26]. However, treatment against the disease can decrease risk of bacterial resistance. The development a suitable antibiotic for the treatment of S. suis infection is also the task of our group [27]. In addition, for prevention of S. suis as well treatment of infections with S. suis, drug use in canada vs us the use of an antiadhesive is essential [28]. In vitro studies indicate the antiadhesive properties of a broad and non-ionic hydrogel with enhanced activity against S. suis strain MSA [29]. Further investigation of the in vivo effect hydrogel is essential to evaluate its therapeutic potential. In conclusion, this study supports the use of S. suis antiadhesive on prevention of disease, and further studies need to evaluate its efficacy.

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