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"When I first saw the pictures of these children, they looked terribly deformed. I was just amazed they survived with these little bodies," says Dr. Mark Molloy, a specialist in infectious diseases surgery at University Hospital of Leicester.
In the 1970s, Molloy studied effectiveness of Bacteriophage, a type antibiotic intended to combat many types of disease, including bacteria caused by a bacterium called Staphylococcus.
However, while it did work to treat a few people infected by Staphylococcus and other bacteria, its effectiveness is generally much lower than that of another drug was commonly used, tetracycline (also known as tetracycline).
Staphylococcus and other bacteria have many proteins they make in order to protect themselves from being killed off by the powerful antibiotic. Some of proteins can build up to the point where they become large-molecule toxins, known as biofilms, that block antibiotics from doing their job.
In a 2013 study the Proceedings of Royal Society, Molloy's team gave the same antibiotic to 30 children born as part of the same study who had been treated and not for infection. As a control, 21 children with similar infections who had not received antibiotics were infected with Staphylococcus.
Molloy found that the Staphylococcus biofilms were completely removed after Bacteriophage treatment for the untreated group of children (those who got the drug). But untreated Staphylococcus biofilms remained present, even after an antibiotic called tetracycline was used in the treatment group of children.
In fact, Molloy where to buy zopiclone cheap found evidence of biofilms that never got eradicated even after they were treated with tetracycline for the Staphylococcus infections. biofilms continued to produce large-molecule toxins, meaning that they continued to kill Staphylococcus bacteria.
In this 2013 study, the staphylococcal biofilms were found in the blood of children even after they were treated with tetracycline. (Image: Dr. Ewan Maclennan, University of Leicester)
In this new study, published the British Journal of Hospital Infection on May 15, Molloy has been testing generic pharmacy online the impact of an antibiotic called bactrim (bactrim, sold under the brand name Bioresource) on biofilms and removing the Staphylococcus from blood samples.
The first thing that happened is the biofilms in blood of children receiving intravenous therapy were gone. This shows that bactrim, at the drug concentration that team chose, does kill the biofilms.
The bactrim that was given to the children also helped clear other infections from these infected individuals' bodies -- like Staphylococcus.
But Molloy found that if the children received a second antibiotic, tetracycline, to treat Bacteria S, they had
zopiclone where to buy to use less of the antibiotic, and even though it was effective did not treat as effectively.
So even though the researchers are not completely sure why the biofilms are still thriving, as where can i buy zopiclone in uk the children were given less of the antibiotic, bacteria may have stayed in a resistant-like state and not been completely destroyed.
"The antibiotic they use to treat it is too strong. These biofilms will come back and try find a way to replicate again," says Molloy.
The good news, however, is that once the biofilms are removed, children were very much healthier than the untreated children.
Molloy says that if the children have a repeat episode of bloodstream infection, he might do a follow-up study of them to test how effective the next antibiotic treatment might be.
Bacteria are known to cause various diseases, including pneumonia, infections causing bleeding and sepsis, even tuberculosis. The most common infections these days are those that caused by bacteria found in food.
Infectious diseases have been a large problem in the United States for decades. CDC says that there were 12.1 million antibiotic-related deaths in 2014 alone and at least 2.7 million people in the
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