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Metoclopramida 10 mg gotas ine and 40 clozapine (two times daily) for 1 week and were then given 20 mg of norketamine (20 once a day), with 10 mg of clozapine (10 once a day) at 7 d. The response was evaluated using TST, VAS, SPSS, SEL, and the Positive Reaction Schedule (RADARS). results did not differ significantly from placebo [ ]. There was no significant difference between treatment groups in terms of VAS scores, except in the PPRS, where there was an effect of norketamine (P =.009). There was also a trend towards better response to treatment in the nornicotine group (P =.07) ( ). Although norketamine was superior to clozapine at reducing the mean duration of hypnosis from 8.4 to 9.5 min in the placebo group (p <.01), this difference was also present in the nornicotine group compared to clozapine (7.5 min v 7.9 min, respectively, p =.07). There was no significant difference between the norketamine and placebo groups in terms of PPRS scores, although this may have been attributable to the fact that PPRS scores were taken in the second session of both treatment groups ( ), as opposed to in the first session of nornicotine group ( ). The mean dose of norketamine administered in the nornicotine group was similar to that administered in the treatment group as a whole (7.5 mg for 6 h) [ ]. There was an improvement in the total score on Positive Reaction Schedule after 6 h [ ]. In addition, the number of positive events decreased from a high of 28% on the baseline to 10% final night of the protocol ( ). At baseline, the total score on RDS was 14 and the total reaction time was 7.6 min [ ]. On the initial day of nornicotine administration, the RDS for sleep improved slightly from 5.7 to 6.6 on average, but the reaction times decreased slightly, from 15.8 to 14.0. No change occurred between placebo and nornicotine groups in respect of the number to report, awakenings, and intensity of hypnosis other effects in the sleep laboratory on 2 days before the second night. decrease in number of awakenings between the first and second day in the nornicotine group was greater than that observed in placebo. Subjects rated the overall severity of hypnosis session using the Positive Reaction Schedule and VAS scores obtained at 1, 2, and 3 h following the first and last hypnosis sessions, respectively. In the nornicotine group, overall scores for positive reactions decreased between 1 and 2 h after the first, compared with a decrease of 13% for placebo. In the nornicotine group, VAS scores decreased over time for hypnosis (t = 3.1; p.04 and t = 7.7; p <.001 and t = 5.9; p.006 respectively). For VASs in the first night nornicotine group, there was an effect of norketamine (P <.02) with decreased effects when considering the first and second night, as there were no significant difference from the placebo group ( ). On the second night, in nornicotine group, there was an effect of nornicotine on the VAS scores compared with placebo group (t = 9.1; p.005). After receiving the 20 mg dose of nornicotine administered over 2 days in the nornicotine group, total duration of hypnosis was significantly reduced from 8.4 to 9.5 min [ ]. In addition, the number of positive events, as measured by the RDS, decreased significantly from a high of 33% after the 10 min first session to 2.2% at the end of both sessions. No other significant change was found between the second and third hypnosis sessions. The percentage of correct responses was calculated for participants who achieved more than 15% correct responses. In the placebo group, 50% of subjects received more than 15% correct while 45% received less than 15% [ ]. The percentage of correct responses in the nornicotine group was significantly higher than that in the control condition. At baseline and every hypnosis session, there was a significant trend towards lower percentages of correct responses in the placebo group ( ). There was also a trend in favour of the nornicotine group, as opposed to the placebo group, for total reaction times, which peaked at 24.5 min in the first hypnosis session and increased to 33.3 min after hypnosis in the last session.
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